In 2006, Huda moved to , since her father was offered a teaching position there. A few years later, Huda moved to Los Angeles, where she studied makeup. Among her clients were celebrities such as and . Huda then returned to Dubai where she became employed by as a makeup artist. In April 2010, upon the advice of one of her sisters, Huda started a beauty-related blog which she named «Huda Beauty» on which she would post makeup tutorials and tips.
In 2013, Huda founded a cosmetics line which, like her blog, is also called «Huda Beauty.» Her first product, a series of false eyelashes, was released through . The Huda Beauty label achieved success with the sales of the false eyelashes, which were famously worn by .
Huda’s company, which is based out of Dubai, later began to offer other beauty products, including eye shadow palettes, liquid lipsticks, lip liners, highlighter palettes, foundations, concealers, baking powders and liquid eyeshadows.
Huda achieved popularity on , attaining more than 35 million followers as of 2019. Huda is ranked #1 on the «2017 Influencer Instagram Rich List», earning $18,000 for each post of sponsored content. Huda has been described as «a Kim Kardashian West of the beauty influencer economy», and was declared one of the «ten most powerful influencers in the world of beauty» by magazine. She was chosen as one of «The 25 Most Influential People on the Internet» by magazine in 2017.
In 2018, Huda began starring in her own original reality series entitled , alongside her family.